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Reason elderly are susceptible to West Nile unclear, expert says

By Jim Erickson

Rocky Mountain News, August 6, 2003

Conventional wisdom tells us that the elderly are more likely to die from West Nile virus because their immune systems are weak and they can't fight off the infection.

Not so, says Dr. Roy Campbell, a medical epidemiologist at the Centers for Disease Control and Prevention in Fort Collins.

"It's an urban legend," Campbell said Tuesday after health officials announced that a 77-year-old Greeley woman became Colorado's first human West Nile virus fatality.

Family members said the woman suffered numerous health problems that weakened her and made her susceptible to West Nile. But most West Nile victims - including the elderly ones - do not have impaired immune systems, Campbell said.

"The reason age seems to be a risk factor for severe illness with West Nile infections is unknown," Campbell said. "There's nothing that you can generalize about increasing age that explains why this happens."

But it does happen.

Last year, 284 Americans were killed by West Nile. The average age of the victims was 77.5. They ranged in age from 19 to 99, and 64 percent of them were male.

Ninety-two percent of last year's fatalities (261 of 284) involved West Nile encephalitis, an inflammation of the brain that causes swelling, cell death and numerous complications, said Campbell, who recently submitted a summary of the 2002 West Nile epidemic to the New England Journal of Medicine.

Fifteen of last year's West Nile victims died from meningitis, an inflammation of the membranes that envelop the brain and spinal cord.

Seven of the 284 deaths were blamed on West Nile fever, a normally mild illness that can include fever, headaches, body aches, a skin rash on the chest and swollen lymph nodes.

One of the 284 deaths was unclassified.

Since West Nile fever sufferers rarely die and often don't seek medical attention, West Nile fatality rates are computed by counting the number of meningitis and encephalitis patients who die.

Last year, 9.4 percent of West Nile encephalitis and meningitis patients died in the United States. That figure is comparable to the death rate in recent West Nile epidemics in Romania, Israel and Russia, Campbell said.

Colorado's 72 West Nile cases include 50 West Nile fever cases, 13 meningitis and nine encephalitis cases.

One death out of 22 severe Colorado illnesses is a fatality rate of just 4.5 percent, but that number is likely to rise as the summer wears on, Campbell said.

"I can almost guarantee you that, as the season goes along, somewhere around 10 percent of encephalitis cases will be fatal," he said.

It's impossible to predict how many West Nile illnesses and deaths Colorado will record in 2003.

Factors affecting the final outcome include: the abundance of the virus in wild birds; the number of mosquitoes and their species; the proximity of mosquitoes to human populations; the West Nile infection rate among those mosquitoes; personal protective action taken by Coloradans; mosquito-control efforts implemented by cities; and weather.

"All these things can interplay into whether or not humans become infected and to what extent," said Dan O'Leary, CDC's West Nile surveillance coordinator.

"It's extremely complex, and science has never been able to validly estimate how many cases will occur in a given area in a given epidemic," O'Leary said.

Last year, two-thirds of this country's West Nile encephalitis and meningitis cases occurred during a five-week period from mid-August to mid-September, said Dr. Tony Marfin, a CDC medical epidemiologist.

"The peak of the epidemic is ahead of us," Marfin said.


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