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Three Proteins May Lead to Alzheimer's
UPI
January 20, 2010
World
U.S. researchers say three proteins may contribute to Alzheimer's disease.
Researchers from the Translational Genomics Research Institute in Phoenix have identified three kinases -- or proteins -- that dismantle connections within brain cells.
The study, published in BMC Genomics, found the kinases -- EIF2AK2, DYRK1A and AKAP13 -- cause a malfunction in tau, a protein critical to the brain cell.
"The ultimate result of tau dysfunction is that neurons lose their connections to other neurons, and when neurons are no longer communicating, that has profound effects on cognition -- the ability to think and reason," Dr. Travis Dunckley, the senior author, said in a statement.
Dunckley and colleagues created tests to look at all 572 known and theoretical kinases within human cells and identified 26 associated with the formation of tau and the three found to cause tau dysfunction.
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