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  Prescriptions for elderly often inappropriate: study

By: Unknown Author

Reuters Health

 August 15, 2002

NEW YORK (Reuters Health) - As many as 12.5% of Finnish seniors may be taking an inappropriate drug, a new study has found.

"Multiple drug use is common in elderly patients because of an increase in the number of medical conditions as one ages," write lead author Dr. Kaisu H. Pitkala of the Helsinki University Hospital in Finland and colleagues.

This increases the risk of harmful drug interactions and adverse side-effects, as well as the likelihood that patients won't comply with their prescribed drug regimen, the researchers note in the August 12/26 issue of the Archives of Internal Medicine.

A panel of experts has established criteria for appropriate drugs for elderly patients, as well as inappropriate drugs for those with certain medical conditions. These criteria were updated in 1997.

To investigate how often elderly patients were prescribed drugs that these criteria deemed inappropriate, the researchers mailed questionnaires to 3,921 people aged 75, 80, 85, 90 and 95.

"Of the respondents, 12.5%, 1.3% and 0.2% were taking at least 1, 2, or 3 inappropriate drugs, respectively," the authors write.

Dipyridamole, an anti-clotting medication, and long-acting benzodiazepines, a type of sedative, topped the list of inappropriately prescribed medicines. Nearly 4% of patients reported taking dipyridamole, while almost 3% had been prescribed benzodiazepines.

And among patients with chronic obstructive pulmonary disease, Pitkala and colleagues found, 27% were taking beta-blockers, which could further impair breathing. Nineteen percent were taking potentially breath-suppressing sedatives.

Roughly 32% of diabetics taking oral medications to bring down blood sugar or insulin also took beta-blockers, which may hide symptoms of low blood sugar. Nearly 38% of patients with blood vessel disease in their extremities, or peripheral vascular disease, were also taking beta-blockers, which have the potential of intensifying leg pain.

"Compared with previous surveys, the use of inappropriate medications in our home-dwelling, elderly population is conspicuously low," the researchers report. "In contrast, use of certain drugs considered inappropriate with different medical conditions was relatively high."

Pitkala and colleagues conclude their report by noting that the prescribing of inappropriate medications may be a result of physicians using "inflexible and explicit" criteria to make their decisions.

SOURCE: Archives of Internal Medicine 2002;162:1707-1712.


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